InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLHL10

Summary

InnateDB Protein

IDBP-49949.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLHL10

Protein Name

kelch-like 10 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000293303

InnateDB Gene

IDBG-49947 (KLHL10)

Protein Structure

UniProt Annotation

Function

May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Spermatogenic failure 11 (SPGF11) [MIM:615081]: An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Oligozoospermia is usually observed in SPGF11 patients. In addition to oligozoospermia, teratozoospermia and moderate asthenozoospermia is observed in some cases. {ECO:0000269PubMed:17047026}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0007286	spermatid development
GO:0008584	male gonad development
GO:0009566	fertilization
GO:0016567	protein ubiquitination
GO:0048808	male genitalia morphogenesis
GO:0048873	homeostasis of number of cells within a tissue

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt