Version 5.4
Homo sapiens Protein: CCDC80
Summary
InnateDB Protein IDBP-49963.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCDC80
Protein Name coiled-coil domain containing 80
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000206423
InnateDB Gene IDBG-49961 (CCDC80)
Protein Structure
UniProt Annotation
Function Promotes cell adhesion and matrix assembly. {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in dermal papilla and dermal fibroblasts (at protein level). Expressed in heart, thymus, placenta, pancreas, colon, epithelium, spleen and osteoblasts. {ECO:0000269PubMed:15325258, ECO:0000269PubMed:15563452, ECO:0000269PubMed:15998583}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
Biological Process
GO:0010811 positive regulation of cell-substrate adhesion
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005604 basement membrane
GO:0005614 interstitial matrix
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q76M96
PhosphoSite PhosphoSite-Q76M96
TrEMBL
UniProt Splice Variant
Entrez Gene 151887
UniGene Hs.734505
RefSeq NP_955806
HUGO HGNC:30649
OMIM 608298
CCDS CCDS2968
HPRD 10508
IMGT
EMBL AB052098 AF506819 AK075210 AL833034 AY333429 AY526612 AY548106 AY548107 BC042105 BC073164 BC086876 BC110842 BC116178 BX647117 BX647817 CH471052
GenPept AAH42105 AAH73164 AAH86876 AAI10843 AAI16179 AAM33633 AAQ96742 AAS66643 AAS66644 AAS92235 BAC11475 BAD05134 CAH56167 CAH56178 CAH56325 EAW79663 EAW79665

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca