Version 5.4
Homo sapiens Protein: NKX2-8
Summary
InnateDB Protein IDBP-4997.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKX2-8
Protein Name NK2 homeobox 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000258829
InnateDB Gene IDBG-4995 (NKX2-8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001889 liver development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007409 axonogenesis
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0050680 negative regulation of epithelial cell proliferation
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
PFAM PF00046
PRINTS PR00024
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15522
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 26257
UniGene Hs.234763
RefSeq NP_055175
HUGO HGNC:16364
OMIM 603245
CCDS CCDS9660
HPRD 04456
IMGT
EMBL AF000295 AF000296 AF000297 AK313537 BC041090
GenPept AAC71081 AAC71082 AAH41090 BAG36314

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca