InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACLY

Summary

InnateDB Protein

IDBP-49994.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACLY

Protein Name

ATP citrate lyase

Synonyms

ACL; ATPCL; CLATP;

Species

Homo sapiens

Ensembl Protein

ENSP00000345398

InnateDB Gene

IDBG-49990 (ACLY)

Protein Structure

UniProt Annotation

Function

ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. {ECO:0000269PubMed:23932781}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	44 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003878	ATP citrate synthase activity
GO:0004775	succinate-CoA ligase (ADP-forming) activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding
GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
GO:0048037	cofactor binding

Biological Process

GO:0006101	citrate metabolic process
GO:0006112	energy reserve metabolic process
GO:0006200	ATP catabolic process
GO:0008152	metabolic process
GO:0008610	lipid biosynthetic process
GO:0015936	coenzyme A metabolic process
GO:0019432	triglyceride biosynthetic process
GO:0031325	positive regulation of cellular metabolic process
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044262	cellular carbohydrate metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009346	citrate lyase complex
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002020 Citrate synthase-like
IPR003781 CoA-binding
IPR005811 ATP-citrate lyase/succinyl-CoA ligase
IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
IPR014608 ATP-citrate synthase
IPR016102 Succinyl-CoA synthetase-like
IPR016141 Citrate synthase-like, core

PFAM

PF00285
PF02629
PF13380
PF00549
PF08442

PRINTS

PR00143

PIRSF

PIRSF036511

SMART

SM00881

TIGRFAMs

Post-translational Modifications

Modification

Cross-References