InnateDB Protein
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IDBP-50039.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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XRCC2
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Protein Name
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X-ray repair complementing defective repair in Chinese hamster cells 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000352271
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InnateDB Gene
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IDBG-50037 (XRCC2)
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Protein Structure
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Function |
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. {ECO:0000269PubMed:11751635, ECO:0000269PubMed:11834724, ECO:0000269PubMed:21276791, ECO:0000269PubMed:23149936}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:21276791}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:21276791}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
18
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013632
DNA recombination and repair protein Rad51, C-terminal
IPR020588
DNA recombination and repair protein RecA-like, ATP-binding domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF08423
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O43543
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PhosphoSite |
PhosphoSite-O43543
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
7516
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UniGene |
Hs.647093
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RefSeq |
NP_005422
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HUGO |
HGNC:12829
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OMIM |
600375
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CCDS |
CCDS5933
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HPRD |
02656
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IMGT |
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EMBL |
AC003109
AF035587
AF520762
AK313607
BC042137
CH471173
Y08837
Y17033
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GenPept |
AAC05369
AAC05802
AAH42137
AAM55241
BAG36372
CAA70065
CAA76597
EAW53968
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