InnateDB Protein
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IDBP-50134.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TMEM216
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Protein Name
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transmembrane protein 216
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000334844
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InnateDB Gene
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IDBG-50132 (TMEM216)
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Protein Structure
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Function |
Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. {ECO:0000269PubMed:22282472}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:22282472}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
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Disease Associations |
Joubert syndrome 2 (JBTS2) [MIM:608091]: A disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. {ECO:0000269PubMed:20036350, ECO:0000269PubMed:20512146, ECO:0000269PubMed:22282472, ECO:0000269PubMed:22425360}. Note=The disease is caused by mutations affecting the gene represented in this entry.Meckel syndrome 2 (MKS2) [MIM:603194]: A disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. {ECO:0000269PubMed:20512146}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019184
Uncharacterised protein family, transmembrane-17
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PFAM |
PF09799
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9P0N5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51259
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UniGene |
Hs.26745
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RefSeq |
NP_001167462
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HUGO |
HGNC:25018
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OMIM |
613277
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CCDS |
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HPRD |
14439
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IMGT |
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EMBL |
AF151078
AK303687
AP003108
BC011010
CR457166
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GenPept |
AAF36164
AAH11010
BAH14017
CAG33447
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