InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASSF2

Summary

InnateDB Protein

IDBP-50174.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASSF2

Protein Name

Ras association (RalGDS/AF-6) domain family member 2

Synonyms

CENP-34; RASFADIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000368710

InnateDB Gene

IDBG-50172 (RASSF2)

Protein Structure

UniProt Annotation

Function

Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. {ECO:0000269PubMed:12732644, ECO:0000269PubMed:16012945, ECO:0000269PubMed:19525978}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines. {ECO:0000269PubMed:12732644}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.

Experimentally validated
Total	46 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0038168	epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade
GO:0045667	regulation of osteoblast differentiation
GO:0045670	regulation of osteoclast differentiation
GO:0046849	bone remodeling
GO:0048872	homeostasis of number of cells
GO:1901222	regulation of NIK/NF-kappaB signaling
GO:1901223	negative regulation of NIK/NF-kappaB signaling