InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SAMD4B

Summary

InnateDB Protein

IDBP-50207.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAMD4B

Protein Name

sterile alpha motif domain containing 4B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000317224

InnateDB Gene

IDBG-50205 (SAMD4B)

Protein Structure

UniProt Annotation

Function

Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269PubMed:20510020}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20510020}. Nucleus {ECO:0000269PubMed:20510020}.

Disease Associations

Tissue Specificity

Widely expressed in embryonic and adult tissues. {ECO:0000269PubMed:20510020}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF07647
PF00536

PRINTS

PIRSF

SMART

SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5PRF9