InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IRS2

Summary

InnateDB Protein

IDBP-50215.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRS2

Protein Name

insulin receptor substrate 2

Synonyms

IRS-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000365016

InnateDB Gene

IDBG-50213 (IRS2)

Protein Structure

UniProt Annotation

Function

May mediate the control of various cellular processes by insulin.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005158	insulin receptor binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0019904	protein domain specific binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002903	negative regulation of B cell apoptotic process
GO:0006006	glucose metabolic process
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007420	brain development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009749	response to glucose
GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport
GO:0010907	positive regulation of glucose metabolic process
GO:0019216	regulation of lipid metabolic process
GO:0030335	positive regulation of cell migration
GO:0030879	mammary gland development
GO:0030890	positive regulation of B cell proliferation
GO:0032000	positive regulation of fatty acid beta-oxidation
GO:0032024	positive regulation of insulin secretion
GO:0032869	cellular response to insulin stimulus
GO:0033673	negative regulation of kinase activity
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0046326	positive regulation of glucose import
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0055088	lipid homeostasis
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0071333	cellular response to glucose stimulus
GO:1901653	cellular response to peptide