Version 5.4
Homo sapiens Protein: SYT7
Summary
InnateDB Protein IDBP-50229.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYT7
Protein Name synaptotagmin VII
Synonyms IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII;
Species Homo sapiens
Ensembl Protein ENSP00000263846
InnateDB Gene IDBG-50227 (SYT7)
Protein Structure
UniProt Annotation
Function May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in a variety of adult and fetal tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
Biological Process
GO:0006887 exocytosis
Cellular Component
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR001565 Synaptotagmin
PFAM PF00168
PRINTS PR00360
PR00399
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43581
PhosphoSite PhosphoSite-O43581
TrEMBL F5H8G7
UniProt Splice Variant
Entrez Gene 9066
UniGene Hs.684589
RefSeq NP_004191
HUGO HGNC:11514
OMIM 604146
CCDS CCDS31577
HPRD 11965
IMGT
EMBL AF038535 AP002754 AP003108 AP003559 BC125170 BC125171 CH471076
GenPept AAB92667 AAI25171 EAW73956

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca