Version 5.4
Homo sapiens Protein: HTR5A
Summary
InnateDB Protein IDBP-50237.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTR5A
Protein Name 5-hydroxytryptamine (serotonin) receptor 5A
Synonyms 5-HT5A;
Species Homo sapiens
Ensembl Protein ENSP00000287907
InnateDB Gene IDBG-50235 (HTR5A)
Protein Structure
UniProt Annotation
Function This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004993 serotonin receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007210 serotonin receptor signaling pathway
GO:0007420 brain development
GO:0019933 cAMP-mediated signaling
GO:0021766 hippocampus development
GO:0032355 response to estradiol
Cellular Component
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0043204 perikaryon
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001397 5-Hydroxytryptamine 5A receptor
IPR002231 5-hydroxytryptamine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PR00518
PR01101
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P47898
PhosphoSite PhosphoSite-P47898
TrEMBL Q86UN1
UniProt Splice Variant
Entrez Gene 3361
UniGene Hs.65791
RefSeq NP_076917
HUGO HGNC:5300
OMIM 601305
CCDS CCDS5936
HPRD 03198
IMGT
EMBL AC092628 AC093726 AF498985 AK094255 BC112021 CH236962 CH471149 X81411 X81412
GenPept AAI12022 AAM21132 AAP21864 AAS07542 BAG52850 CAA57168 EAL23726 EAX04526

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca