InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP6V1E2

Summary

InnateDB Protein

IDBP-50338.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1E2

Protein Name

ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000304891

InnateDB Gene

IDBG-403302 (ATP6V1E2)

Protein Structure

UniProt Annotation

Function

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Testis specific. {ECO:0000269PubMed:12036578}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0006811	ion transport
GO:0006879	cellular iron ion homeostasis
GO:0008286	insulin receptor signaling pathway
GO:0015986	ATP synthesis coupled proton transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0033572	transferrin transport
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation