InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNH4

Summary

InnateDB Protein

IDBP-50427.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNH4

Protein Name

potassium voltage-gated channel, subfamily H (eag-related), member 4

Synonyms

BEC2; ELK1; Kv12.3;

Species

Homo sapiens

Ensembl Protein

ENSP00000264661

InnateDB Gene

IDBG-50425 (KCNH4)

Protein Structure

UniProt Annotation

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Detected only in brain, in particular in the telencephalon. Detected in putamen and caudate nucleus, and at lower levels in cerebral cortex, occipital and hippocampus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000155	phosphorelay sensor kinase activity
GO:0004871	signal transducer activity
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006355	regulation of transcription, DNA-templated
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0023014	signal transduction by phosphorylation
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000014 PAS domain
IPR000595 Cyclic nucleotide-binding domain
IPR000700 PAS-associated, C-terminal
IPR001610 PAC motif
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
IPR003950 Potassium channel, voltage-dependent, ELK
IPR003967 Potassium channel, voltage-dependent, ERG
IPR005821 Ion transport domain
IPR013099 Two pore domain potassium channel domain
IPR013655 PAS fold-3
IPR013656 PAS fold-4
IPR013767 PAS fold
IPR018490 Cyclic nucleotide-binding-like

PFAM