InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZDHHC21

Summary

InnateDB Protein

IDBP-50772.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZDHHC21

Protein Name

zinc finger, DHHC-type containing 21

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000370303

InnateDB Gene

IDBG-50770 (ZDHHC21)

Protein Structure

UniProt Annotation

Function

Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0016409	palmitoyltransferase activity
GO:0019706	protein-cysteine S-palmitoyltransferase activity

Biological Process

GO:0001942	hair follicle development
GO:0018230	peptidyl-L-cysteine S-palmitoylation
GO:0018345	protein palmitoylation
GO:0044281	small molecule metabolic process
GO:0046209	nitric oxide metabolic process
GO:0048733	sebaceous gland development
GO:0050999	regulation of nitric-oxide synthase activity