InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CER1

Summary

InnateDB Protein

IDBP-50821.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CER1

Protein Name

cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)

Synonyms

DAND4;

Species

Homo sapiens

Ensembl Protein

ENSP00000370297

InnateDB Gene

IDBG-50819 (CER1)

Protein Structure

UniProt Annotation

Function

Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0016015	morphogen activity
GO:0036122	BMP binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001657	ureteric bud development
GO:0003419	growth plate cartilage chondrocyte proliferation
GO:0007369	gastrulation
GO:0007399	nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0009948	anterior/posterior axis specification
GO:0009952	anterior/posterior pattern specification
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030282	bone mineralization
GO:0030509	BMP signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0035582	sequestering of BMP in extracellular matrix
GO:0042074	cell migration involved in gastrulation
GO:0048263	determination of dorsal identity
GO:0071773	cellular response to BMP stimulus
GO:2000381	negative regulation of mesoderm development