InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DCN

Summary

InnateDB Protein

IDBP-50874.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCN

Protein Name

decorin

Synonyms

CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000052754

InnateDB Gene

IDBG-50872 (DCN)

Protein Structure

UniProt Annotation

Function

May affect the rate of fibrils formation.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Corneal dystrophy, congenital stromal (CSCD) [MIM:610048]: A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0005539	glycosaminoglycan binding
GO:0044822	poly(A) RNA binding
GO:0047485	protein N-terminus binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001822	kidney development
GO:0001890	placenta development
GO:0005975	carbohydrate metabolic process
GO:0007519	skeletal muscle tissue development
GO:0007568	aging
GO:0009612	response to mechanical stimulus
GO:0009887	organ morphogenesis
GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030207	chondroitin sulfate catabolic process
GO:0030208	dermatan sulfate biosynthetic process
GO:0032496	response to lipopolysaccharide
GO:0042060	wound healing
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005589	collagen type VI trimer
GO:0005615	extracellular space
GO:0005796	Golgi lumen
GO:0031012	extracellular matrix
GO:0043202	lysosomal lumen

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR016352 Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan

PFAM

PF01462
PF00560
PF13504
PF13855

PRINTS

PIRSF

PIRSF002490

SMART

SM00013
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt