Version 5.4
Homo sapiens Protein: KIAA0141
Summary
InnateDB Protein IDBP-50998.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIAA0141
Protein Name KIAA0141
Synonyms DELE;
Species Homo sapiens
Ensembl Protein ENSP00000194118
InnateDB Gene IDBG-50996 (KIAA0141)
Protein Structure
UniProt Annotation
Function Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation. {ECO:0000269PubMed:20563667}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:20563667}.
Disease Associations
Tissue Specificity Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon. {ECO:0000269PubMed:8590280}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR006597 Sel1-like
PFAM PF08238
PRINTS
PIRSF
SMART SM00671
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14154
PhosphoSite PhosphoSite-Q14154
TrEMBL
UniProt Splice Variant
Entrez Gene 9812
UniGene Hs.607496
RefSeq XP_005268604
HUGO HGNC:28969
OMIM 615741
CCDS CCDS4268
HPRD 13780
IMGT
EMBL BC007855 BC010452 BC011269 BC011926 D50931
GenPept AAH07855 AAH10452 AAH11269 AAH11926 BAA09490

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca