InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PCDH12

Summary

InnateDB Protein

IDBP-51057.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCDH12

Protein Name

protocadherin 12

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000231484

InnateDB Gene

IDBG-51055 (PCDH12)

Protein Structure

UniProt Annotation

Function

Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Cell junction.

Disease Associations

Tissue Specificity

Expressed in highly vascularized tissues including the heart and placenta, but most tissues contain a low level of expression. Prominent expression in the spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0005977	glycogen metabolic process
GO:0007156	homophilic cell adhesion
GO:0008038	neuron recognition
GO:0016339	calcium-dependent cell-cell adhesion
GO:0060711	labyrinthine layer development

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome