InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EEF1G

Summary

InnateDB Protein

IDBP-51082.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EEF1G

Protein Name

eukaryotic translation elongation factor 1 gamma

Synonyms

EF1G; GIG35;

Species

Homo sapiens

Ensembl Protein

ENSP00000331901

InnateDB Gene

IDBG-547100 (EEF1G)

Protein Structure

UniProt Annotation

Function

Probably plays a role in anchoring the complex to other cellular components.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in pancreatic tumor tissue and to a lesser extent in normal kidney, intestine, pancreas, stomach, lung, brain, spleen and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 160 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	160 [view]
Protein-Protein	159 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0005515	protein binding

Biological Process

GO:0006412	translation
GO:0006414	translational elongation
GO:0009615	response to virus
GO:0010467	gene expression
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001662 Translation elongation factor EF1B, gamma chain, conserved
IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM