Version 5.4
Homo sapiens Protein: UPK1B
Summary
InnateDB Protein IDBP-51087.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UPK1B
Protein Name uroplakin 1B
Synonyms TSPAN20; UPIB; UPK1;
Species Homo sapiens
Ensembl Protein ENSP00000264234
InnateDB Gene IDBG-51085 (UPK1B)
Protein Structure
UniProt Annotation
Function Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Bladder epithelium.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
GO:0030855 epithelial cell differentiation
Cellular Component
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000301 Tetraspanin
IPR008952 Tetraspanin, EC2 domain
IPR018499 Tetraspanin/Peripherin
PFAM PF00335
PRINTS PR00259
PIRSF PIRSF002419
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75841
PhosphoSite PhosphoSite-O75841
TrEMBL E7ETN9
UniProt Splice Variant
Entrez Gene 7348
UniGene Hs.598308
RefSeq NP_008883
HUGO HGNC:12578
OMIM 602380
CCDS CCDS2985
HPRD 03853
IMGT
EMBL AB002155 AB015234 AC083800 AF042331 AF067147 AF082888 BC063568
GenPept AAC17446 AAC77794 AAD09401 AAH63568 BAA33724 BAA88878

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca