InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNKSR2

Summary

InnateDB Protein

IDBP-51155.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNKSR2

Protein Name

connector enhancer of kinase suppressor of Ras 2

Synonyms

CNK2; KSR2; MAGUIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000279451

InnateDB Gene

IDBG-51153 (CNKSR2)

Protein Structure

UniProt Annotation

Function

May function as an adapter protein or regulator of Ras signaling pathways. {ECO:0000269PubMed:14597674}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0009966

regulation of signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001478 PDZ domain
IPR001660 Sterile alpha motif domain
IPR001849 Pleckstrin homology domain
IPR010599 Connector enhancer of kinase suppressor of ras 2
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR019555 CRIC domain, Chordata
IPR021129 Sterile alpha motif, type 1

PFAM