InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDFIP1

Summary

InnateDB Protein

IDBP-51200.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDFIP1

Protein Name

Nedd4 family interacting protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000253814

InnateDB Gene

IDBG-51196 (NDFIP1)

Protein Structure

UniProt Annotation

Function

Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate. {ECO:0000250, ECO:0000269PubMed:19343052, ECO:0000269PubMed:19706893, ECO:0000269PubMed:20534535}.

Subcellular Localization

Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane {ECO:0000250}. Secreted. Note=Detected in exosomes and secreted via the exosomal pathway.

Disease Associations

Tissue Specificity

Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung. {ECO:0000269PubMed:11748237}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0050699	WW domain binding

Biological Process

GO:0002761	regulation of myeloid leukocyte differentiation
GO:0002829	negative regulation of type 2 immune response
GO:0006879	cellular iron ion homeostasis
GO:0007165	signal transduction
GO:0010629	negative regulation of gene expression
GO:0031398	positive regulation of protein ubiquitination
GO:0032410	negative regulation of transporter activity
GO:0032713	negative regulation of interleukin-4 production
GO:0042130	negative regulation of T cell proliferation
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045619	regulation of lymphocyte differentiation
GO:0045732	positive regulation of protein catabolic process
GO:0048294	negative regulation of isotype switching to IgE isotypes
GO:0048302	regulation of isotype switching to IgG isotypes
GO:0050728	negative regulation of inflammatory response
GO:0051224	negative regulation of protein transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005794	Golgi apparatus
GO:0005938	cell cortex
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm