InnateDB Protein
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IDBP-51203.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ESYT2
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Protein Name
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extended synaptotagmin-like protein 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000251527
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InnateDB Gene
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IDBG-51201 (ESYT2)
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Protein Structure
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Function |
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. {ECO:0000269PubMed:17360437, ECO:0000269PubMed:20833364, ECO:0000269PubMed:23791178, ECO:0000269PubMed:24847877}.
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Subcellular Localization |
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Detected at sites of contact between the endoplasmic reticulum membrane and the cell membrane. Recruited to the cell membrane via the third C2 domain.
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Disease Associations |
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Tissue Specificity |
Widely expressed with high level in cerebellum. {ECO:0000269PubMed:17360437}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000008
C2 domain
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PFAM |
PF00168
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PRINTS |
PR00360
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PIRSF |
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SMART |
SM00239
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TIGRFAMs |
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Modification |
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SwissProt |
A0FGR8
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PhosphoSite |
PhosphoSite-A0FGR8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57488
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UniGene |
Hs.649908
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RefSeq |
NP_065779
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HUGO |
HGNC:22211
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OMIM |
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CCDS |
CCDS34791
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HPRD |
13053
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IMGT |
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EMBL |
AB033054
AJ303365
AK001181
AK124091
AK126214
AL833233
AY368150
BC013957
CH236954
DQ993201
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GenPept |
AAH13957
AAR89381
ABJ97706
BAA86542
BAA91539
BAC85769
BAC86489
CAC33887
CAH10642
EAL23931
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