InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTA2

Summary

InnateDB Protein

IDBP-51225.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTA2

Protein Name

metastasis associated 1 family, member 2

Synonyms

MTA1L1; PID;

Species

Homo sapiens

Ensembl Protein

ENSP00000278823

InnateDB Gene

IDBG-51223 (MTA2)

Protein Structure

UniProt Annotation

Function

May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00512, ECO:0000255PROSITE-ProRule:PRU00624}.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 147 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	147 [view]
Protein-Protein	145 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000989	transcription factor binding transcription factor activity
GO:0001085	RNA polymerase II transcription factor binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031492	nucleosomal DNA binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0006333	chromatin assembly or disassembly
GO:0006355	regulation of transcription, DNA-templated
GO:0016575	histone deacetylation
GO:0043044	ATP-dependent chromatin remodeling
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000118	histone deacetylase complex
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0016020	membrane
GO:0016581	NuRD complex
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000679 Zinc finger, GATA-type
IPR000949 ELM2 domain
IPR001005 SANT/Myb domain
IPR001025 Bromo adjacent homology (BAH) domain
IPR009057 Homeodomain-like

PFAM

PF00320
PF01448
PF00249
PF01426

PRINTS

PR00619

PIRSF

SMART

SM00401
SM00717
SM00439

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt