InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VIPR2

Summary

InnateDB Protein

IDBP-51264.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VIPR2

Protein Name

vasoactive intestinal peptide receptor 2

Synonyms

C16DUPq36.3; DUP7q36.3; PACAP-R-3; PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R;

Species

Homo sapiens

Ensembl Protein

ENSP00000262178

InnateDB Gene

IDBG-51262 (VIPR2)

Protein Structure

UniProt Annotation

Function

This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. {ECO:0000269PubMed:8926282}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in CD4+ T-cells, but not in CD8+ T- cells. Expressed in the T-cell lines Jurkat, Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78. {ECO:0000269PubMed:8926282}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004999	vasoactive intestinal polypeptide receptor activity

Biological Process

GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007267	cell-cell signaling
GO:0048662	negative regulation of smooth muscle cell proliferation

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001571 GPCR, family 2, vasoactive intestinal peptide receptor
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR002284 GPCR, family 2, vasoactive intestinal peptide receptor 2
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR00491
PR01155

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt