InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNMT3L

Summary

InnateDB Protein

IDBP-5127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNMT3L

Protein Name

DNA (cytosine-5-)-methyltransferase 3-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000270172

InnateDB Gene

IDBG-5125 (DNMT3L)

Protein Structure

UniProt Annotation

Function

Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3. {ECO:0000269PubMed:17687327}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed at low levels in several tissues including testis, ovary, and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0019899	enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0006306	DNA methylation
GO:0006349	regulation of gene expression by genetic imprinting
GO:0007283	spermatogenesis
GO:0045892	negative regulation of transcription, DNA-templated