InnateDB Protein
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IDBP-51373.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GANAB
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Protein Name
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glucosidase, alpha; neutral AB
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Synonyms
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G2AN; GLUII;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000340466
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InnateDB Gene
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IDBG-51371 (GANAB)
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Protein Structure
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Function |
Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. {ECO:0000269PubMed:10929008}.
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Subcellular Localization |
Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Melanosome {ECO:0000269PubMed:10929008, ECO:0000269PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
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Disease Associations |
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Tissue Specificity |
Detected in placenta. {ECO:0000269PubMed:3881423}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
67
[view]
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Protein-Protein |
67
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000322
Glycoside hydrolase, family 31
IPR011013
Galactose mutarotase-like domain
IPR017853
Glycoside hydrolase, superfamily
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PFAM |
PF01055
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14697
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PhosphoSite |
PhosphoSite-Q14697
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23193
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UniGene |
Hs.706921
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RefSeq |
NP_938149
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HUGO |
HGNC:4138
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OMIM |
104160
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CCDS |
CCDS41656
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HPRD |
03516
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IMGT |
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EMBL |
AF144074
AJ000332
AP001458
BC017433
BC017435
BC065266
D42041
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GenPept |
AAF66685
AAH17433
AAH17435
AAH65266
BAA07642
CAA04006
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