Version 5.4
Homo sapiens Protein: SERTAD1
Summary
InnateDB Protein IDBP-51525.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERTAD1
Protein Name SERTA domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000350633
InnateDB Gene IDBG-51523 (SERTAD1)
Protein Structure
UniProt Annotation
Function Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351 transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR009263 SERTA domain
PFAM PF06031
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHV2
PhosphoSite PhosphoSite-
TrEMBL Q53GC0
UniProt Splice Variant
Entrez Gene 29950
UniGene Hs.269898
RefSeq NP_037508
HUGO HGNC:17932
OMIM
CCDS CCDS12557
HPRD 15326
IMGT
EMBL AF117959 AF366402 AK074652 AK222970 AK223011 AY130860 BC002670 CH471126
GenPept AAF08349 AAH02670 AAK52831 AAM77800 BAD96690 BAD96731 BAG51982 EAW56964 EAW56965

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca