Version 5.4
Homo sapiens Protein: ERLEC1
Summary
InnateDB Protein IDBP-51697.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERLEC1
Protein Name endoplasmic reticulum lectin 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367485
InnateDB Gene IDBG-51695 (ERLEC1)
Protein Structure
UniProt Annotation
Function Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins. {ECO:0000269PubMed:16531414, ECO:0000269PubMed:18264092, ECO:0000269PubMed:18502753}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000269PubMed:16531414, ECO:0000269PubMed:18502753}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
Biological Process
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
Protein Structure and Domains
PDB ID
InterPro IPR009011 Mannose-6-phosphate receptor binding domain
IPR012913 Glucosidase II beta subunit-like
PFAM PF07915
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96DZ1
PhosphoSite PhosphoSite-Q96DZ1
TrEMBL
UniProt Splice Variant
Entrez Gene 27248
UniGene Hs.438336
RefSeq NP_001120870
HUGO HGNC:25222
OMIM 611229
CCDS CCDS46284
HPRD 10310
IMGT
EMBL AC007883 AF131743 AF131849 AK001913 AK315477 AY358717 AY453410 BC013129 BC022228 CH471053
GenPept AAD20029 AAD20060 AAH13129 AAH22228 AAQ89079 AAR26725 AAY24352 BAA91974 BAG37861 EAX00164

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca