Version 5.4
Homo sapiens Protein: HMHB1
Summary
InnateDB Protein IDBP-51763.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMHB1
Protein Name histocompatibility (minor) HB-1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000289448
InnateDB Gene IDBG-51761 (HMHB1)
Protein Structure
UniProt Annotation
Function Precursor of the histocomplatibility antigen HB-1. More generally, minor histocomplatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA- identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocomplatibility antigen in HLA-matched sibling marrow transplants. HB-1 is presented on the cell surface by MHC class I HLA-B44. This complex specifically elicits donor-cytotoxic T lymphocyte (CTL) reactivity in B-cell acute lymphoblastic leukemia (B-ALL) after treatment by HLA-identical allogenic bone marrow transplantation (BMT). It induces cell recognition and lysis by CTL. However, HB-1 restricted expression in B-ALL cells and not in normal tissues may allow a specific CTL reactivity against B-ALL without the risk of evoking graft-versus-host disease. {ECO:0000269PubMed:15102363, ECO:0000269PubMed:8992968, ECO:0000269PubMed:9892612}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in acute lymphoblastic leukemia B- cells and Epstein-Barr virus-transformed B-cells. {ECO:0000269PubMed:8992968, ECO:0000269PubMed:9892612}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002376 immune system process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O97980
PhosphoSite PhosphoSite-O97980
TrEMBL
UniProt Splice Variant
Entrez Gene 57824
UniGene Hs.158320
RefSeq NP_067005
HUGO HGNC:29677
OMIM 609961
CCDS CCDS43376
HPRD 17089
IMGT
EMBL AF103884 AF233094 BC104412 BC104413
GenPept AAC78642 AAF81110 AAI04413 AAI04414

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca