InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLR2G

Summary

InnateDB Protein

IDBP-51799.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLR2G

Protein Name

polymerase (RNA) II (DNA directed) polypeptide G

Synonyms

hRPB19; hsRPB7; RPB19; RPB7;

Species

Homo sapiens

Ensembl Protein

ENSP00000301788

InnateDB Gene

IDBG-51797 (POLR2G)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA. {ECO:0000250, ECO:0000269PubMed:9852112}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9852112}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003697	single-stranded DNA binding
GO:0003727	single-stranded RNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0031369	translation initiation factor binding

Biological Process

GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic
GO:0000398	mRNA splicing, via spliceosome
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006351	transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0006915	apoptotic process
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016032	viral process
GO:0045948	positive regulation of translational initiation
GO:0050434	positive regulation of viral transcription
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005665	DNA-directed RNA polymerase II, core complex
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

InterPro

IPR003029 Ribosomal protein S1, RNA-binding domain
IPR005576 RNA polymerase Rpb7, N-terminal
IPR012340 Nucleic acid-binding, OB-fold
IPR013238 RNA polymerase III, subunit Rpc25
IPR022967 RNA-binding domain, S1

PFAM

PF00575
PF03876
PF08292

PRINTS

PIRSF

SMART

SM00316

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P62487