InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PSME3

Summary

InnateDB Protein

IDBP-51811.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSME3

Protein Name

proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)

Synonyms

HEL-S-283; Ki; PA28-gamma; PA28G; PA28gamma; REG-GAMMA;

Species

Homo sapiens

Ensembl Protein

ENSP00000293362

InnateDB Gene

IDBG-51809 (PSME3)

Protein Structure

UniProt Annotation

Function

Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. {ECO:0000269PubMed:10835274, ECO:0000269PubMed:11185562, ECO:0000269PubMed:11432824, ECO:0000269PubMed:15111123, ECO:0000269PubMed:18309296, ECO:0000269PubMed:9325261}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10657252, ECO:0000269PubMed:12629132}. Cytoplasm {ECO:0000250}. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	92 [view]
Protein-Protein	89 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0061133	endopeptidase activator activity
GO:0097371	MDM2/MDM4 family protein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006521	regulation of cellular amino acid metabolic process
GO:0006915	apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467	gene expression
GO:0010950	positive regulation of endopeptidase activity
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0061136	regulation of proteasomal protein catabolic process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0008537	proteasome activator complex
GO:0016020	membrane