Version 5.4
Homo sapiens Protein: SH3RF2
Summary
InnateDB Protein IDBP-51910.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3RF2
Protein Name protein phosphatase 1, regulatory subunit 39
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000352028
InnateDB Gene IDBG-51908 (SH3RF2)
Protein Structure
UniProt Annotation
Function Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function. {ECO:0000269PubMed:19389623, ECO:0000269PubMed:19945436, ECO:0000305}.
Subcellular Localization
Disease Associations
Tissue Specificity Heart (at protein level). Heart and testis. In the heart, present in the apex, left atrium, right atrium, left ventricle and right ventricle, but not in the aorta. {ECO:0000269PubMed:19945436}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
GO:0005515 protein binding
GO:0008157 protein phosphatase 1 binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0019902 phosphatase binding
GO:0046872 metal ion binding
Biological Process
GO:0010923 negative regulation of phosphatase activity
GO:0016567 protein ubiquitination
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR001841 Zinc finger, RING-type
IPR011511 Variant SH3 domain
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF00018
PF14604
PF13639
PF14634
PF07653
PF00097
PRINTS PR00452
PIRSF
SMART SM00326
SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TEC5
PhosphoSite PhosphoSite-Q8TEC5
TrEMBL
UniProt Splice Variant
Entrez Gene 153769
UniGene Hs.443728
RefSeq NP_689763
HUGO HGNC:26299
OMIM 613377
CCDS CCDS4280
HPRD 10229
IMGT
EMBL AC005216 AC005351 AC011359 AC091887 AK058046 AK074234 AK292576 BC031650 BC073914 BC125106
GenPept AAH31650 AAH73914 AAI25107 BAB71639 BAB85025 BAF85265

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca