InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STXBP5L

Summary

InnateDB Protein

IDBP-51946.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STXBP5L

Protein Name

syntaxin binding protein 5-like

Synonyms

LLGL4;

Species

Homo sapiens

Ensembl Protein

ENSP00000273666

InnateDB Gene

IDBG-51944 (STXBP5L)

Protein Structure

UniProt Annotation

Function

May play a role in vesicle trafficking and exocytosis. {ECO:0000305}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected in kidney, hippocampus and lung carcinoma. {ECO:0000269PubMed:14767561}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019905	syntaxin binding

Biological Process

GO:0006887	exocytosis
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0017157	regulation of exocytosis
GO:0042593	glucose homeostasis
GO:0046676	negative regulation of insulin secretion
GO:0050714	positive regulation of protein secretion

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000664 Lethal(2) giant larvae protein
IPR001388 Synaptobrevin
IPR001680 WD40 repeat
IPR013577 Lethal giant larvae homologue 2
IPR013905 Lethal giant larvae (Lgl)-like, C-terminal domain
IPR017986 WD40-repeat-containing domain

PFAM

PF00957
PF00400
PF08366
PF08596

PRINTS

PR00962
PR00219

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt