InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX53

Summary

InnateDB Protein

IDBP-51970.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX53

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 53

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368667

InnateDB Gene

IDBG-51966 (DDX53)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Nucleus {ECO:0000269PubMed:11922625}.

Disease Associations

Tissue Specificity

Expressed in testis. Wide expression in various cancer tissues and cancer cell lines. {ECO:0000269PubMed:11922625}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity

Biological Process

GO:0006200

ATP catabolic process

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR004087 K Homology domain
IPR004088 K Homology domain, type 1
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00013
PF13014
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00322
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86TM3