Version 5.4
Homo sapiens Protein: LTA4H
Summary
InnateDB Protein IDBP-51979.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LTA4H
Protein Name leukotriene A4 hydrolase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000228740
InnateDB Gene IDBG-51977 (LTA4H)
Protein Structure
UniProt Annotation
Function Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. {ECO:0000269PubMed:11917124, ECO:0000269PubMed:12207002, ECO:0000269PubMed:15078870, ECO:0000269PubMed:18804029, ECO:0000269PubMed:1897988, ECO:0000269PubMed:1975494, ECO:0000269PubMed:2244921}.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 11 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0004301 epoxide hydrolase activity
GO:0004463 leukotriene-A4 hydrolase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006508 proteolysis
GO:0006691 leukotriene metabolic process
GO:0006954 inflammatory response
GO:0019369 arachidonic acid metabolic process
GO:0019370 leukotriene biosynthetic process
GO:0043171 peptide catabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR012777 Leukotriene A4 hydrolase
IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
IPR016024 Armadillo-type fold
PFAM PF01433
PF09127
PRINTS PR00756
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P09960
PhosphoSite PhosphoSite-P09960
TrEMBL Q49AK0
UniProt Splice Variant
Entrez Gene 4048
UniGene Hs.524648
RefSeq NP_000886
HUGO HGNC:6710
OMIM 151570
CCDS CCDS9059
HPRD 01056
IMGT
EMBL AC007298 AK298017 BC032528 BC036555 BX647158 CH471054 CR457068 J02959 J03459 U27275 U27276 U27277 U27278 U27279 U27280 U27281 U27282 U27283 U27284 U27285 U27286 U27287 U27288 U27289 U27290 U27291 U27292 U27293 U43410 U43411
GenPept AAA36176 AAA36177 AAA89077 AAH32528 AAH36555 BAG60321 CAG33349 EAW97559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca