Version 5.4
Homo sapiens Protein: PTCHD1
Summary
InnateDB Protein IDBP-51999.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTCHD1
Protein Name patched domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000368666
InnateDB Gene IDBG-51997 (PTCHD1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cell membrane {ECO:0000269PubMed:20844286}; Multi-pass membrane protein {ECO:0000269PubMed:20844286}.
Disease Associations
Tissue Specificity Widely expressed, including in various regions of the brain with highest expression in the gray and white cerebellum, followed by the cerebellar vermis and the pituitary gland. {ECO:0000269PubMed:20844286}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008158 hedgehog receptor activity
Biological Process
GO:0007224 smoothened signaling pathway
GO:0050890 cognition
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000731 Sterol-sensing domain
IPR003392 Patched
PFAM PF02460
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96NR3
PhosphoSite PhosphoSite-
TrEMBL X5DNX9
UniProt Splice Variant
Entrez Gene 139411
UniGene Hs.609897
RefSeq NP_775766
HUGO HGNC:26392
OMIM 300828
CCDS CCDS35215
HPRD 06548
IMGT
EMBL AC073910 AK054858 AK298796 BC062344 BC121061 KJ534921
GenPept AAH62344 AAI21062 AHW56561 BAB70816 BAG60932

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca