InnateDB Protein
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IDBP-52039.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ELK3
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Protein Name
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ELK3, ETS-domain protein (SRF accessory protein 2)
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Synonyms
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ERP; NET; SAP2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000228741
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InnateDB Gene
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IDBG-52037 (ELK3)
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Protein Structure
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Function |
May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0003714
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transcription corepressor activity
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GO:0005515
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protein binding
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GO:0032422
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purine-rich negative regulatory element binding
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000418
Ets domain
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PFAM |
PF00178
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PRINTS |
PR00454
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PIRSF |
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SMART |
SM00413
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TIGRFAMs |
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Modification |
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SwissProt |
P41970
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PhosphoSite |
PhosphoSite-P41970
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TrEMBL |
F8VZQ0
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UniProt Splice Variant |
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Entrez Gene |
2004
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UniGene |
Hs.733727
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RefSeq |
NP_005221
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HUGO |
HGNC:3325
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OMIM |
600247
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CCDS |
CCDS9060
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HPRD |
02593
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IMGT |
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EMBL |
AC008149
AK312694
BC017371
CH471054
CR542251
Z36715
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GenPept |
AAH17371
BAG35573
CAA85309
CAG47047
EAW97561
EAW97563
EAW97564
EAW97565
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