Version 5.4
Homo sapiens Protein: ITPKC
Summary
InnateDB Protein IDBP-52096.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITPKC
Protein Name inositol-trisphosphate 3-kinase C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263370
InnateDB Gene IDBG-52094 (ITPKC)
Protein Structure
UniProt Annotation
Function Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12747803}. Cytoplasm {ECO:0000269PubMed:12747803}. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.
Disease Associations Kawasaki disease (KWD) [MIM:611775]: An acute, self- limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy. {ECO:0000269PubMed:18157129}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain. {ECO:0000269PubMed:11085927}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity
GO:0016301 kinase activity
Biological Process
GO:0016310 phosphorylation
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR005522 Inositol polyphosphate kinase
PFAM PF03770
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96DU7
PhosphoSite PhosphoSite-Q96DU7
TrEMBL A0A024R0N8
UniProt Splice Variant
Entrez Gene 80271
UniGene Hs.515415
RefSeq NP_079470
HUGO HGNC:14897
OMIM 606476
CCDS CCDS12563
HPRD 09400
IMGT
EMBL AJ290975 BC060788 CH471126 D38169 Y11999
GenPept AAH60788 BAA22524 CAA72728 CAC40815 EAW56992 EAW56993

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca