InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: F7

Summary

InnateDB Protein

IDBP-52196.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

coagulation factor VII (serum prothrombin conversion accelerator)

Synonyms

SPCA;

Species

Homo sapiens

Ensembl Protein

ENSP00000364731

InnateDB Gene

IDBG-52192 (F7)

Protein Structure

UniProt Annotation

Function

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

Subcellular Localization

Secreted.

Disease Associations

Factor VII deficiency (FA7D) [MIM:227500]: A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. {ECO:0000269PubMed:10862079, ECO:0000269PubMed:11091194, ECO:0000269PubMed:11129332, ECO:0000269PubMed:12472587, ECO:0000269PubMed:14717781, ECO:0000269PubMed:1634227, ECO:0000269PubMed:18976247, ECO:0000269PubMed:19432927, ECO:0000269PubMed:19751712, ECO:0000269PubMed:2070047, ECO:0000269PubMed:21206266, ECO:0000269PubMed:21372693, ECO:0000269PubMed:7974346, ECO:0000269PubMed:7981691, ECO:0000269PubMed:8043443, ECO:0000269PubMed:8204879, ECO:0000269PubMed:8364544, ECO:0000269PubMed:8652821, ECO:0000269PubMed:8844208, ECO:0000269PubMed:8883260, ECO:0000269PubMed:8940045, ECO:0000269PubMed:9414278, ECO:0000269PubMed:9452082, ECO:0000269PubMed:9576180}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0003824	catalytic activity
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005102	receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0002690	positive regulation of leukocyte chemotaxis
GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0007598	blood coagulation, extrinsic pathway
GO:0007623	circadian rhythm
GO:0009725	response to hormone
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0014070	response to organic cyclic compound
GO:0017187	peptidyl-glutamic acid carboxylation
GO:0030194	positive regulation of blood coagulation
GO:0030335	positive regulation of cell migration
GO:0031100	organ regeneration
GO:0031667	response to nutrient levels
GO:0032571	response to vitamin K
GO:0043627	response to estrogen
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0050927	positive regulation of positive chemotaxis
GO:0051897	positive regulation of protein kinase B signaling
GO:0060416	response to growth hormone

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0031982	vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
IPR000742 Epidermal growth factor-like domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR001881 EGF-like calcium-binding domain
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR015420 Peptidase S1A, nudel

PFAM

PF00594
PF00008
PF00089
PF07645
PF09342

PRINTS

PR00001
PR00722

PIRSF

PIRSF001143

SMART

SM00069
SM00181
SM00020
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References