Homo sapiens Protein: SLC22A6 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-52245.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | SLC22A6 | ||||||||||||||||||
Protein Name | solute carrier family 22 (organic anion transporter), member 6 | ||||||||||||||||||
Synonyms | HOAT1; OAT1; PAHT; ROAT1; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000353597 | ||||||||||||||||||
InnateDB Gene | IDBG-52241 (SLC22A6) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate. {ECO:0000250, ECO:0000269PubMed:12538807, ECO:0000269PubMed:15644426, ECO:0000269PubMed:17038320, ECO:0000269PubMed:17502342, ECO:0000269PubMed:9762842, ECO:0000269PubMed:9887087}. | ||||||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule. {ECO:0000269PubMed:10049739, ECO:0000269PubMed:10462545, ECO:0000269PubMed:10964714, ECO:0000269PubMed:9887087, ECO:0000269PubMed:9950961}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR004749
Organic cation transport protein IPR005828 General substrate transporter IPR011701 Major facilitator superfamily IPR016196 Major facilitator superfamily domain, general substrate transporter IPR020846 Major facilitator superfamily domain |
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PFAM |
PF00083
PF07690 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q4U2R8 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q4U2R8 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 9356 | ||||||||||||||||||
UniGene | Hs.369252 | ||||||||||||||||||
RefSeq | NP_695008 | ||||||||||||||||||
HUGO | HGNC:10970 | ||||||||||||||||||
OMIM | 607582 | ||||||||||||||||||
CCDS | CCDS8041 | ||||||||||||||||||
HPRD | 12125 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB009697 AB009698 AF057039 AF097490 AF104038 AF124373 AJ249369 AJ251529 AJ271205 AP001858 BC033682 CH471076 EU567146 | ||||||||||||||||||
GenPept | AAC70004 AAD10052 AAD19356 AAD55356 AAH33682 ACB21049 BAA75072 BAA75073 CAB77184 CAB94830 CAB97249 EAW74129 EAW74130 EAW74131 EAW74132 | ||||||||||||||||||