InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: F10

Summary

InnateDB Protein

IDBP-52277.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F10

Protein Name

coagulation factor X

Synonyms

FX; FXA;

Species

Homo sapiens

Ensembl Protein

ENSP00000364709

InnateDB Gene

IDBG-52275 (F10)

Protein Structure

UniProt Annotation

Function

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

Subcellular Localization

Secreted.

Disease Associations

Factor X deficiency (FA10D) [MIM:227600]: A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis. {ECO:0000269PubMed:10468877, ECO:0000269PubMed:10746568, ECO:0000269PubMed:11248282, ECO:0000269PubMed:11728527, ECO:0000269PubMed:12945883, ECO:0000269PubMed:15650540, ECO:0000269PubMed:17393015, ECO:0000269PubMed:19135706, ECO:0000269PubMed:1973167, ECO:0000269PubMed:1985698, ECO:0000269PubMed:2790181, ECO:0000269PubMed:7669671, ECO:0000269PubMed:7860069, ECO:0000269PubMed:8529633, ECO:0000269PubMed:8845463, ECO:0000269PubMed:8910490}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Plasma; synthesized in the liver. {ECO:0000269PubMed:6587384}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005543	phospholipid binding

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0007598	blood coagulation, extrinsic pathway
GO:0017187	peptidyl-glutamic acid carboxylation
GO:0030335	positive regulation of cell migration
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005576	extracellular region
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031233	intrinsic to external side of plasma membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
IPR000742 Epidermal growth factor-like domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR001881 EGF-like calcium-binding domain
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z

PFAM

PF00594
PF00008
PF00089
PF07645

PRINTS

PR00001
PR00722

PIRSF

PIRSF001143

SMART

SM00069
SM00181
SM00020
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References