InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP2A6

Summary

InnateDB Protein

IDBP-52292.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2A6

Protein Name

cytochrome P450, family 2, subfamily A, polypeptide 6

Synonyms

CPA6; CYP2A; CYP2A3; CYPIIA6; P450C2A; P450PB;

Species

Homo sapiens

Ensembl Protein

ENSP00000301141

InnateDB Gene

IDBG-547391 (CYP2A6)

Protein Structure

UniProt Annotation

Function

Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4- cineole 2-exo-monooxygenase. Possesses low phenacetin O- deethylation activity. {ECO:0000269PubMed:11695850, ECO:0000269PubMed:16086027, ECO:0000269PubMed:17125252, ECO:0000269PubMed:18779312, ECO:0000269PubMed:1889415, ECO:0000269PubMed:1944238}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Liver. {ECO:0000269PubMed:1889415, ECO:0000269PubMed:1944238}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008389	coumarin 7-hydroxylase activity
GO:0009055	electron carrier activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825	oxygen binding
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0050381	unspecific monooxygenase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0009804	coumarin metabolic process
GO:0017144	drug metabolic process
GO:0042738	exogenous drug catabolic process
GO:0044281	small molecule metabolic process
GO:0046226	coumarin catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005792	microsome
GO:0005881	cytoplasmic microtubule
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008067 Cytochrome P450, E-class, group I, CYP2A-like

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00465
PR01684

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11509