Homo sapiens Protein: CYP2A7
Summary
InnateDB Protein IDBP-52294.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP2A7
Protein Name cytochrome P450, family 2, subfamily A, polypeptide 7
Synonyms CPA7; CPAD; CYP2A; CYPIIA7; P450-IIA4;
Species Homo sapiens
Ensembl Protein ENSP00000301146
InnateDB Gene IDBG-52290 (CYP2A7)
Protein Structure
UniProt Annotation
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular Localization Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008067 Cytochrome P450, E-class, group I, CYP2A-like
IPR008068 Cytochrome P450, E-class, group I, CYP2B-like
PFAM PF00067
PRINTS PR00385
PR00463
PR00465
PR01684
PR01685
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P20853
PhosphoSite PhosphoSite-P20853
TrEMBL
UniProt Splice Variant
Entrez Gene 1549
UniGene
RefSeq NP_000755
HUGO HGNC:2611
OMIM 608054
CCDS CCDS12569
HPRD 07453
IMGT
EMBL AC008537 M33317 U22029
GenPept AAA52138 AAB40520