InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BMP2

Summary

InnateDB Protein

IDBP-52332.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMP2

Protein Name

bone morphogenetic protein 2

Synonyms

BDA2; BMP2A;

Species

Homo sapiens

Ensembl Protein

ENSP00000368104

InnateDB Gene

IDBG-52330 (BMP2)

Protein Structure

UniProt Annotation

Function

Induces cartilage and bone formation.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004745	retinol dehydrogenase activity
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0019211	phosphatase activator activity
GO:0046332	SMAD binding
GO:0046982	protein heterodimerization activity
GO:0070700	BMP receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000187	activation of MAPK activity
GO:0001501	skeletal system development
GO:0001649	osteoblast differentiation
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001837	epithelial to mesenchymal transition
GO:0001934	positive regulation of protein phosphorylation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002062	chondrocyte differentiation
GO:0003130	BMP signaling pathway involved in heart induction
GO:0003181	atrioventricular valve morphogenesis
GO:0003203	endocardial cushion morphogenesis
GO:0003308	negative regulation of Wnt receptor signaling pathway involved in heart development
GO:0006029	proteoglycan metabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0007219	Notch signaling pathway
GO:0007267	cell-cell signaling
GO:0007507	heart development
GO:0008285	negative regulation of cell proliferation
GO:0009790	embryo development
GO:0009887	organ morphogenesis
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010894	negative regulation of steroid biosynthetic process
GO:0010922	positive regulation of phosphatase activity
GO:0021537	telencephalon development
GO:0021978	telencephalon regionalization
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030198	extracellular matrix organization
GO:0030282	bone mineralization
GO:0030335	positive regulation of cell migration
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0031648	protein destabilization
GO:0032348	negative regulation of aldosterone biosynthetic process
GO:0033690	positive regulation of osteoblast proliferation
GO:0035051	cardiac cell differentiation
GO:0035054	embryonic heart tube anterior/posterior pattern specification
GO:0035630	bone mineralization involved in bone maturation
GO:0040007	growth
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042482	positive regulation of odontogenesis
GO:0042487	regulation of odontogenesis of dentin-containing tooth
GO:0043065	positive regulation of apoptotic process
GO:0043410	positive regulation of MAPK cascade
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045165	cell fate commitment
GO:0045597	positive regulation of cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045778	positive regulation of ossification
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048711	positive regulation of astrocyte differentiation
GO:0048762	mesenchymal cell differentiation
GO:0048839	inner ear development
GO:0051042	negative regulation of calcium-independent cell-cell adhesion
GO:0055007	cardiac muscle cell differentiation
GO:0055008	cardiac muscle tissue morphogenesis
GO:0055114	oxidation-reduction process
GO:0060039	pericardium development
GO:0060128	corticotropin hormone secreting cell differentiation
GO:0060129	thyroid-stimulating hormone-secreting cell differentiation
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0060395	SMAD protein signal transduction
GO:0060485	mesenchyme development
GO:0060804	positive regulation of Wnt receptor signaling pathway by BMP signaling pathway
GO:0061036	positive regulation of cartilage development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071363	cellular response to growth factor stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071773	cellular response to BMP stimulus
GO:0072138	mesenchymal cell proliferation involved in ureteric bud development
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1900745	positive regulation of p38MAPK cascade
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:2000065	negative regulation of cortisol biosynthetic process
GO:2000726	negative regulation of cardiac muscle cell differentiation

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0009986	cell surface

Protein Structure and Domains

PDB ID

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR00669

PIRSF

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt