Version 5.4
Homo sapiens Protein: FMN1
Summary
InnateDB Protein IDBP-5235.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FMN1
Protein Name formin 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000333950
InnateDB Gene IDBG-404008 (FMN1)
Protein Structure
UniProt Annotation
Function Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Localization to the adherens junctions is alpha-catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions and to microtubules (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0016043 cellular component organization
GO:0030036 actin cytoskeleton organization
GO:0045010 actin nucleation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005912 adherens junction
Protein Structure and Domains
PDB ID
InterPro IPR001265 Formin homology family, Cappuccino subfamily
IPR015425 Formin, FH2 domain
PFAM PF02181
PRINTS PR00828
PIRSF
SMART SM00498
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q68DA7
PhosphoSite PhosphoSite-Q68DA7
TrEMBL
UniProt Splice Variant
Entrez Gene 342184
UniGene Hs.657649
RefSeq NP_001096654
HUGO HGNC:3768
OMIM 136535
CCDS CCDS45209
HPRD
IMGT
EMBL AC018515 AC019278 AC090098 AC090877 AC090982 AK127078 BC103692 BC107593 CR749487
GenPept AAI03693 AAI07594 CAH18313

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca