Version 5.4
Homo sapiens Protein: HAUS6
Summary
InnateDB Protein IDBP-52375.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAUS6
Protein Name HAUS augmin-like complex, subunit 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000369871
InnateDB Gene IDBG-52373 (HAUS6)
Protein Structure
UniProt Annotation
Function Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269PubMed:19029337, ECO:0000269PubMed:19369198, ECO:0000269PubMed:19427217}.
Subcellular Localization Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007067 mitotic nuclear division
GO:0051225 spindle assembly
GO:0051297 centrosome organization
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005874 microtubule
GO:0070652 HAUS complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z4H7
PhosphoSite PhosphoSite-Q7Z4H7
TrEMBL Q5SYF9
UniProt Splice Variant
Entrez Gene 54801
UniGene Hs.682466
RefSeq NP_060115
HUGO HGNC:25948
OMIM 613433
CCDS CCDS6489
HPRD 13302
IMGT
EMBL AB046794 AF533709 AF537091 AK000067 AK022964 AK023068 AK056458 AK301852 AL356000 AL591206 BC010632 BC026178 BC065935 BC071625 BC111041 BC113981 BC114492
GenPept AAH10632 AAH26178 AAH65935 AAH71625 AAI11042 AAI13982 AAI14493 AAN05700 AAQ09022 BAA90922 BAB13400 BAB14334 BAB14388 BAG51716 BAG63294 CAH72133 CAI12264

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca