InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PROZ

Summary

InnateDB Protein

IDBP-52390.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PROZ

Protein Name

protein Z, vitamin K-dependent plasma glycoprotein

Synonyms

PZ;

Species

Homo sapiens

Ensembl Protein

ENSP00000344458

InnateDB Gene

IDBG-52386 (PROZ)

Protein Structure

UniProt Annotation

Function

Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0017187	peptidyl-glutamic acid carboxylation
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
IPR000742 Epidermal growth factor-like domain
IPR001254 Peptidase S1
IPR001881 EGF-like calcium-binding domain
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z

PFAM

PF00594
PF00008
PF00089
PF07645

PRINTS

PR00001

PIRSF

PIRSF001143

SMART

SM00069
SM00181
SM00020
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References