Version 5.4
Homo sapiens Protein: SLC22A9
Summary
InnateDB Protein IDBP-52410.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC22A9
Protein Name solute carrier family 22 (organic anion transporter), member 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000279178
InnateDB Gene IDBG-52408 (SLC22A9)
Protein Structure
UniProt Annotation
Function Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes. {ECO:0000269PubMed:17393504}.
Subcellular Localization Basolateral cell membrane {ECO:0000269PubMed:17393504}; Multi-pass membrane protein {ECO:0000269PubMed:17393504}. Note=Enriched at the sinusoidal part of the plasma membrane.
Disease Associations
Tissue Specificity Specifically expressed in liver by hepatocytes (at protein level). {ECO:0000269PubMed:11327718, ECO:0000269PubMed:17393504}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0022857 transmembrane transporter activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF00083
PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IVM8
PhosphoSite PhosphoSite-
TrEMBL A4PB24
UniProt Splice Variant
Entrez Gene 114571
UniGene Hs.502772
RefSeq NP_543142
HUGO HGNC:16261
OMIM 607579
CCDS CCDS8043
HPRD 06982
IMGT
EMBL AB062418 AB074812 AF440402 AJ295270 AK074246 AP000484 AP001880 BC022379 BC126288 CH471076
GenPept AAH22379 AAI26289 AAP97316 BAB83517 BAB85030 BAF51552 CAC82910 EAW74146 EAW74148

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca