Version 5.4
Homo sapiens Protein: SPINK9
Summary
InnateDB Protein IDBP-52449.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPINK9
Protein Name serine peptidase inhibitor, Kazal type 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367139
InnateDB Gene IDBG-52447 (SPINK9)
Protein Structure
UniProt Annotation
Function Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5. {ECO:0000269PubMed:19190773, ECO:0000269PubMed:19194479}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Skin. Highly expressed at sites of hyperkeratosis. Also detected in thymus, tonsils, testis, pancreas, liver, placenta and brain. Expressed at stratum granulosum and stratum corneum at palmar and plantar sites (at protein level). {ECO:0000269PubMed:19190773, ECO:0000269PubMed:19194479}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR001239 Proteinase inhibitor I1, Kazal metazoa
IPR002350 Kazal domain
PFAM PF00050
PF07648
PRINTS PR00290
PIRSF
SMART SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5DT21
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 643394
UniGene Hs.631798
RefSeq NP_001035523
HUGO HGNC:32951
OMIM 613511
CCDS CCDS34269
HPRD
IMGT
EMBL AY396740 BC137530 BC137531
GenPept AAI37531 AAI37532 AAR91618

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca